BIOAVAILABILITY OF BROPIRIMINE 250 MG TABLET IN DOGS - EFFECT OF FOOD

The postprandial effect on the bioavailability of bropirimine in dogs after oral administration of bropirimine tablets (Bropirimine 250 mg T ablet) was investigated. At a dose of 500 mg bropirimine (two tablets of bropirimine 250 mg), the maximum plasma concentration under the pos tprandial condition was about twice that observed under the fasting co ndition, and the area under the plasma concentration vs time curve und er the postprandial condition was also twice that under the fasting co ndition, The absolute oral bioavailabilities of bropirimine were 41.1% under the fasting condition and 83.5% under the postprandial conditio n. It is considered that the longer gastric residence time and larger volume of the gastric fluid induced by food-intake caused the increase in dissolution of bropirimine which increased the bioavailability aft er oral dosing of bropirimine 250-mg tablets.