EVALUATION OF ACRODONTIOLAMIDE, A CHLORINATED COMPOUND PRODUCED BY ACRODONTIUM-SALMONEUM DEHOOG FOR CYTOTOXICITY AND ANTIMICROBIAL ACTIVITY

A new antifungal compound has been isolated from the culture medium of Acrodontium salmoneum de Hoog. Its structure was previously elucidate d and was named acrodontiolamide. However, this compound is not charac teristically produced by the genus Acrodontium, it is rather a feature of one isolate of A. salmoneum coming from the soil of the grotto of La Pierre Saint Martin (France). Production, purification, cytotoxicit y and antimicrobial activities of acrodontiolamide are described. Conc erning microorganisms, inhibitory activity seems to be specifically re stricted to phytopathogenic and entomopathogenic fungi. Acrodontiolami de not cytotoxic to either normal human cultured cells or tumor cells.