PEDIGREE ANALYSIS OF VITILIGO - FURTHER SUPPORT FOR MULTILOCUS INVOLVEMENT

Vitiligo is a dermatological disorder in man that shows familial aggre gation. We performed segregation analysis on data pertaining to vitili go on members of 147 pedigrees each ascertained through a single proba nd, and tested various non-genetic, and one-locus and two-locus geneti c models. Non-genetic and one-locus genetic models were rejected in fa vour of a two-locus model postulating epistatic interaction of recessi ve alleles in the aetiology of vitiligo. The present results show that vitiligo is not a single-locus disorder and substantiate our earlier inference, drawn on the basis of nuclear-family data, of multilocus in volvement in the pathogenesis of vitiligo.