PSEUDOANGIOSARCOMATOUS CARCINOMA OF THE GENITOURINARY TRACT

Two cases of pseudoangiosarcomatous carcinoma of the genitourinary tra ct, arising in the vulva in one and the bladder in the other, are pres ented. In case 1, an 84 year old woman, the vulvectomy specimen contai ned an irregular ulcerated tumour, infiltrating the left labia and ext ending into the clitoris. In case 2, a 59 year old woman, the excised bladder showed diffuse thickening of its wall by infiltrating haemorrh agic tumour. Both tumours showed focal keratinisation. This, in associ ation with the presence of atypical squamous epithelium, immunohistoch emistry and ultrastructural analysis, led to a diagnosis of pseudosarc omatous carcinoma in both cases. Pseudoangiosarcomatous carcinoma shou ld be considered in the differential diagnosis of malignant angiomatoi d tumours, particularly those that arise at sites, like the genitourin ary tract, where angiosarcoma is rare.