HYDROGEN ION-DEPENDENT ONCOGENESIS AND PARALLEL NEW AVENUES TO CANCERPREVENTION AND TREATMENT USING A H-MEDIATED UNIFYING APPROACH - PH-RELATED AND PH-UNRELATED MECHANISMS()

Authors
HARGUINDEY S PEDRAZ JL CANERO RG DEDIEGO JP CRAGOE EJ
Citation
S. Harguindey et al., HYDROGEN ION-DEPENDENT ONCOGENESIS AND PARALLEL NEW AVENUES TO CANCERPREVENTION AND TREATMENT USING A H-MEDIATED UNIFYING APPROACH - PH-RELATED AND PH-UNRELATED MECHANISMS(), Critical reviews in oncogenesis, 6(1), 1995, pp. 1-33
Citations number
303
Categorie Soggetti
Oncology
Journal title
Critical reviews in oncogenesis → ACNP
ISSN journal
08939675
Volume
6
Issue
1
Year of publication
1995
Pages
1 - 33
Database
ISI
SICI code
0893-9675(1995)6:1<1:HIOAPN>2.0.ZU;2-5
Abstract
A comprehensive examination of phenomena related to cancer is presente d that is based on hydrogen ion dynamics, as viewed from the biologica l, biochemical, and biophysical perspective. A model is described that considers an array of cancer-associated events from oncogenesis to ca rcinogenesis from this perspective. The basic ideas are viewed from va rious aspects, ranging from the cellular level to the clinical situati on. The novel types of therapeutic and prophylactic agents that result from applying these concepts are elucidated. Considerable insight int o this modern approach is seen from some of the mechanisms that charac terize the phenomenon of spontaneous regression of cancer.