The authors describe a rare case of diffused thrombosis of the superfi
cial veins in the whole body and periphlebitis with perivascular absce
sses in an human immunodeficiency virus (HIV)-infected drug abuser who
was using neck veins to inject cocaine and heroin. In addition the pa
tient presented oral candidiasis, hepatitis C virus infection, broncho
pneumonitis, and endocarditis of the tricuspid valve with valvular fai
lure. The conditions of the patient needed repeated vascular catheteri
zations for therapy administration. Similar pathologies, in HIV-infect
ed patients, highly increase the risk of opportunistic infections, esp
ecially in the encephalic territory; in addition the need for vascular
catheterizations represents a further risk factor for bacterial infec
tions.