Studying reproduction in domestic species is now possible at the cellu
lar and molecular level due to advances in the production of large num
bers of zygotes and embryos in these species. In this paper we review
the microtubule patterns during fertilization in domestic species. The
se results indicate that domestic species accomplish fertilization in
a similar fashion to one another but in a far different fashion from r
odents. Recent results indicate that human fertilization is similar to
that of domestic species. We discuss the significance this has on the
use of domestic species as a model system for human studies and possi
ble consequences for the alleviation of human infertility.