EFFECT OF A NEW COGNITIVE DRUG-ENHANCER S-12024-2 ON EEG SLEEP RECORDINGS IN RATS

A newly synthesized agent S-12024-2 was shown to improve some aspects of cognitive processes such as memory consolidation. The relationships between sleep and memory lead us to investigate the effects of the in traperitoneal administration of three different doses (1, 3, and 10 mg /kg) of S-12024-2 on sleep variables in the rat. The results showed th at S-12024-2 (10 mg/kg) increased slow wave sleep (SWS) and decreased wakefulness during the light period of the first 24 h of sleep recordi ng. During day 1 of sleep recording, S-12024-2 tended to increase para doxical sleep (PS) with a maximal effect observed with 3 mg/kg. Four d ays after administration of S-12024-2 (3 mg/kg), PS remained significa ntly high. These data suggest an active role for S-12024-2 on SWS and PS, compatible with its favourable effects on memory.