EVIDENCE FOR DOPAMINE-RECEPTOR PRUNING BETWEEN ADOLESCENCE AND ADULTHOOD IN STRIATUM BUT NOT NUCLEUS-ACCUMBENS

Citation
Mh. Teicher et al., EVIDENCE FOR DOPAMINE-RECEPTOR PRUNING BETWEEN ADOLESCENCE AND ADULTHOOD IN STRIATUM BUT NOT NUCLEUS-ACCUMBENS, Developmental brain research, 89(2), 1995, pp. 167-172
Citations number
27
Categorie Soggetti
Neurosciences
ISSN journal
01653806
Volume
89
Issue
2
Year of publication
1995
Pages
167 - 172
Database
ISI
SICI code
0165-3806(1995)89:2<167:EFDPBA>2.0.ZU;2-D
Abstract
Postnatal development of dopamine D-1 and D-2 receptor families in str iatum and nucleus accumbens of rats was studied at 25, 35, 40, 60, 80, 100 and 120 days using autoradiography. These ages were selected to t est the hypothesis that dopamine receptors were overproduced prior to puberty (day 40), and pruned back to adult levels thereafter. This hyp othesis was confirmed in striatum but not nucleus accumbens. D-1 recep tor B-max ([H-3]SCH-23390) peaked at 40 days, with levels 67 +/- 21% g reater than at 25 days. However, B-max levels were at least 35% lower at 60-120 days than at 40 days. Similarly, D-2 receptor numbers ([H-3] YM-09151-2) increased 144 +/- 26% between 25 and 40 days, but were red uced by 34-38% between 60-120 days. In contrast, D-1 and D-2 receptor B-max increase approximately 150% between 25 and 40 days in nucleus ac cumbens, levels fell slightly at 60 or 80 days, but were no different at 100 and 120 days then they were at 40 days. These findings suggest that these two major dopamine target regions follow different developm ental strategies, and this has implications for etiological theories o f schizophrenia that focus on anomalous receptor pruning.