Near Infrared Spectroscopy (NIRS) has been used to detect changes in c
erebral blood and tissue oxygenation. Redox state of enzyme cytochrome
aa(3) (Cyt aa(3)) is thought to give an indication of tissue oxygenat
ion. This information would be of value in exploring the aetiology of
cerebral ischaemic lesions in preterm infants. However we have found t
hat the change in cerebral cytochrome redox in infants following desat
uration was inconsistent and insignificant.