HYDROPHOBIC HYDRATION IN METHANOL AQUEOUS-SOLUTIONS

In this work we present a Monte Carlo study of a methanol-water mixtur e. The model potentials used includes polarization and nonadditive eff ects in the intermolecular interactions. The parameters were fitted to two; and three-body energy surfaces computed ab initio with a basis s et of 2 zeta plus polarization quality. Correlation was included at th e MP2 level, and the basis set superposition error was corrected with the counterpoise method. Very long runs, 20x10(6) configurations, were used to assure that equilibrium was attained. Good agreement with exp eriment was found for the structural data; the carbon to water oxygen and the hydrogen to hydrogen radial distribution functions. We studied the hydrophobic hydration of the methyl group and the effect of the s olute on the water structure. We found that there is hydration of the hydroxyl group and a caging of the methyl group; that the solute does indeed affect the water structure at close distance to the solute but that this effect is masked by the average over the whole system. The w ater structure is disrupted by a slight broadening of the first peak i n the O-O rdf and a shift of the second peak toward larger distances, we have also found that there is some methanol-methanol association. ( C) 1995 American Institute of Physics.