This review outlines the geographic distribution of infection and offe
rs possible explanations for differences in occurrence of infection. E
xperimental studies have shown that there are many possible means of t
ransmission of infection. Direct contact with animals persistently inf
ected (PI) with bovine viral diarrhea virus (BVDV) is probably the mos
t important method of transmission of infection. However, field studie
s have shown that some limited spread of infection also occurs in the
absence of PI animals. Clinical symptoms after BVDV infection often oc
cur within certain time limits, which may help to make the herd diagno
sis. Surveillance of infection status at the herd level is also possib
le using serology because of the extensive transmission of infections
from PI animals. The high incidence of infection combined with the dif
ferent damages that are seen after BVDV infection cause huge economic
losses.