SYNTHESIS, STRUCTURAL CHARACTERIZATION, CRYSTALLOGRAPHIC ANALYSIS ANDANTIBACTERIAL PROPERTIES OF SOME NITROFURYL TRIAZOLO[3,4-B]-1,3,4-THIADIAZINES

A series of 1-(5-nitro-2-furyl)-2-bromo-3-aryl-2-propen-1-ones has bee n prepared through dehydrobromination of 3-dibromo-1-(5-nitro-2-furyl) -3-arylpropan-1-ones. Condensation of 1-(5-nitro-2-furyl)-2-bromo-3-ar yl-2-propen-1-ones with 4-amino-5-mercapto-1,2,4-triazoles afforded a new class of rylidene-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. The st ructure of the condensation products are fully confirmed by analytical , IR, NMR and mass spectral data. The formation of 1,2,4-triazolo[3,4- b]-1,3,4-thiadiazines rather than 1,2,4-triazolo[3,4-b]-1,3,4-thiadiaz epines in the above condensation has also been confirmed by X-ray crys tallographic analysis. The newly synthesized compounds have been scree ned for their in vitro antibacterial activity against Gram-positive an d Gram-negative bacteria.