Background Published reports on patients with cortical blindness descr
ibe bilateral brain hemispheric lesions visualized in radiological and
functional imaging studies. Case Description We present a case with a
unilateral lesion on radiological studies and bilateral abnormalities
on single-photon emission-computed tomographic (SPECT) scanning. Conc
lusions SPECT images correlated much more closely than radiological st
udies with the patient's clinical status. We suggest that SPECT scanni
ng can be a useful indicator of focal brain dysfunction in brain injur
y in spite of normal radiological studies. We also hypothesize that ou
r patient's clinical and functional imaging findings could be attribut
ed in part to the process of diaschisis.