HEPARIN-INDUCED THROMBOCYTOPENIA AND FATAL THROMBOSIS IN A PATIENT WITH ACTIVATED PROTEIN-C RESISTANCE

Authors
GARDYN J SORKIN P KLUGER Y KABILI S KLAUSNER JM ZIVELIN A ELDOR A
Citation
J. Gardyn et al., HEPARIN-INDUCED THROMBOCYTOPENIA AND FATAL THROMBOSIS IN A PATIENT WITH ACTIVATED PROTEIN-C RESISTANCE, American journal of hematology, 50(4), 1995, pp. 292-295
Citations number
16
Categorie Soggetti
Hematology
Journal title
American journal of hematology → ACNP
ISSN journal
03618609
Volume
50
Issue
4
Year of publication
1995
Pages
292 - 295
Database
ISI
SICI code
0361-8609(1995)50:4<292:HTAFTI>2.0.ZU;2-Y
Abstract
We report a 20-year-old woman who developed heparin-induced thrombocyt openia (HIT) associated with devastating and fatal multiorgan thrombos is. The patient, her mother, and her brother were found to have resist ance to activated protein C (APC), and the congenital thrombophilia in this family was verified by the finding of the Arg(506) Gln mutation in factor V. This is the first case of HIT and APC resistance, The con sequences of this association are discussed. (C) 1995 Wiley-Liss, Inc.