IMPROVED SURVIVAL OF PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA UNDERGOING ALLOGENEIC BONE-MARROW TRANSPLANTATION

A total of 28 patients with chronic myelogenous leukemia (CML) in chro nic phase (CP) received bone marrow allografts from HLA-matched siblin gs at the University of Florida between August 1984-July 1992, The pre sent study compares the disease-free survival (DFS) for those patients who were transplanted before or after August 1988 using the same cond itioning regimen, The analysis shows significant difference in 3-year DFS for those patients transplanted post- vs, pre-august 1988 (69.6% v s, 20%, respectively; P = 0.006), A decrease in pneumonitis due to dif ferent etiologies from pre-august 1988 (6/13, 46%) to post-August 1988 (1/15, 7%) was statistically significant (P = 0.029), A decrease, alt hough statistically insignificant, in the overall incidence and severi ty of acute and chronic graft vs, host disease (GVHD) after August 198 8 was also noticed, This study indicates significantly improved outcom e for patients with CML in CP who have been treated in the University of Florida after August 1988, Better supportive care and prophylaxis f or GVHD most likely contributed to such improvement. (C) 1995 Wiley-Li ss, Inc.