FUTURE-DIRECTIONS IN CLINICAL RESEARCH IN WILMS-TUMOR

The success of treatment of most children with Wilms tumor has made tr aditional therapeutic research in this group of patients increasingly difficult. Nevertheless, new insights into the biology of Wilms tumor, and their possible exploitation for the identification of patients at high risk of recurrence, have resulted in renewed confidence that the relatively large proportion of patients with Wilms tumor without thes e high-risk factors can be cured with minimal therapy.