Snails act as intermediate hosts in trematode life cycles, and many st
udies have dealt with the question of how miracidia, mainly of schisto
somes, find and recognize their snail hosts. However, the published re
sults on the chemical snail host cues that attract miracidia of Schist
osoma mansoni have been contradictory. Here, Wilfried Haas, Bernhard H
aberl, Martin Kalbe and Martina Korner review data that indicate that
macromolecular glycoproteins are the attractants, and that schistosome
miracidia can distinguish between snail strains during their chemo-or
ientation towards the hosts. in echinostome life cycles gastropods als
o act as second intermediate hosts and are actively invaded by cercari
ae. However, these cercariae approach their snail hosts with types of
chemo-orientation that differ from those of miracidia, and they respon
d to small molecular host cues.