EFFECTS OF NIFEDIPINE AND DILTIAZEM ON PHARMACOKINETICS OF CEFPODOXIME FOLLOWING ITS ORAL-ADMINISTRATION

We compared the effects of nifedipine and diltiazem on the uptake of c efpodoxime proxetil (CP). The study was aimed at establishing the impa ct of increased mesenteric blood how due to calcium channel blockers o n passive transport. Twelve volunteers were given CP (200 mg) orally i n a crossover design. The absorption, disposition, and elimination par ameters of cefpodoxime were compared among the following three treatme nt groups: CP alone, CP following oral administration of diltiazem (60 mg), or CP following oral administration of nifedipine (20 mg). No st atistically significant difference in pharmacokinetic parameters was o bserved between the three treatment groups.