R. Weiskirchen et al., THE CYSTEINE-RICH PROTEIN FAMILY OF HIGHLY RELATED LIM-DOMAIN PROTEINS, The Journal of biological chemistry, 270(48), 1995, pp. 28946-28954
Here we describe a family of closely related LIM do main proteins in a
vian cells, The LlM motif defines a zinc binding domain that is found
in a variety of transcriptional regulators, proto-oncogene products, a
nd proteins associated with sites of cell substratum con tact, One typ
e of LIM-domain protein, called the cysteine-rich protein (CRP), is ch
aracterized by the presence of two LIM domains linked to short glycine
-rich repeats and a potential nuclear localization signal, We have ide
ntified and characterized two evolutionarily conserved members of the
CRP family, CRP1 and CRP2, in chicken and quail, Expression of the gen
es encoding both CRP1 and CRP2 is differentially regulated in normal v
ersus transformed cells, raising the possibility that members of the C
RP family may function in control of cell growth and differentiation.