THE DISTRIBUTION OF THE HLA-DQ-ALPHA ALLELES AND GENOTYPES IN THE TURKISH POPULATION AS DETERMINED BY THE USE OF DNA AMPLIFICATION AND ALLELE-SPECIFIC OLIGONUCLEOTIDES
S. Menevse et U. Ulkuer, THE DISTRIBUTION OF THE HLA-DQ-ALPHA ALLELES AND GENOTYPES IN THE TURKISH POPULATION AS DETERMINED BY THE USE OF DNA AMPLIFICATION AND ALLELE-SPECIFIC OLIGONUCLEOTIDES, Science & justice, 35(4), 1995, pp. 259-262
Allele and genotype frequencies for the HLA-DQ alpha locus were determ
ined for use in forensic analyses in Turkey. The polymerase chain reac
tion and the reverse dot blot format were employed to detect six diffe
rent HLA DQ alpha alleles, which were detected among 150 unrelated ind
ividuals with allele frequencies ranging from 7% to 26.7%. The distrib
ution of the observed genotypes was in Hardy-Weinberg equilibrium. The
discrimination power of this system in the Turkish population sample
was 0.94, and the allelic diversity was 0.81. This study provides supp
ort for the validity of the HLA-DQ alpha procedure for typing forensic
samples.