TREATMENT OF ENTERIC FEVER WITH PEFLOXACIN FOR 7 DAYS VERSUS 5 DAYS -A RANDOMIZED CLINICAL-TRIAL

Authors
UNAL S HAYRAN M TUNCER S GUR D UZUN O AKOVA M AKALIN HE
Citation
S. Unal et al., TREATMENT OF ENTERIC FEVER WITH PEFLOXACIN FOR 7 DAYS VERSUS 5 DAYS -A RANDOMIZED CLINICAL-TRIAL, Antimicrobial agents and chemotherapy, 40(12), 1996, pp. 2898-2900
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
40
Issue
12
Year of publication
1996
Pages
2898 - 2900
Database
ISI
SICI code
0066-4804(1996)40:12<2898:TOEFWP>2.0.ZU;2-W
Abstract
In this prospective study of enteric fever, 22 patients received 400 m g of pefloxacin twice daily for 5 days (group A) and 24 received 400 m g of pefloxacin twice daily for 7 days (group B). Causative microorgan isms were Salmonella typhi (8 in group A, 11 in group B) and Salmonell a paratyphi B (14 in group A, 13 in group B). The clinical cure and ba cterial eradication rates were 96% (21 of 22) in group A and 100% in g roup B. In conclusion, 5-day oral administration of pefloxacin was as effective as 7-day treatment of enteric fever caused by Salmonella spp .