DOES TREATMENT WITH TESTOSTERONE UNDECANOATE IMPROVE THE IN-VITRO FERTILIZING-CAPACITY OF SPERMATOZOA IN PATIENTS WITH IDIOPATHIC TESTICULAR FAILURE - (RESULTS OF A DOUBLE-BLIND-STUDY)
F. Comhaire et al., DOES TREATMENT WITH TESTOSTERONE UNDECANOATE IMPROVE THE IN-VITRO FERTILIZING-CAPACITY OF SPERMATOZOA IN PATIENTS WITH IDIOPATHIC TESTICULAR FAILURE - (RESULTS OF A DOUBLE-BLIND-STUDY), Human reproduction, 10(10), 1995, pp. 2600-2602
Seventy-seven couples in whom conventional in-vitro fertilization (IVF
) had remained unsuccessful because of low fertilization rate and abno
rmal sperm characteristics were given either testosterone undecanoate
120 mg/day, or placebo during 3 months, after which a new IVF treatmen
t was applied under identical technical conditions. There were no sign
ificant changes in sperm characteristics among the treated and placebo
couples and the fertilization rate showed a similar increase after tr
eatment in both groups. No significant difference in pregnancies occur
red, with 32% pregnancies in the placebo controls and 17% among couple
s treated with testosterone undecanoate. It is concluded that testoste
rone undecanoate intake does not improve sperm characteristics, or the
in-vitro fertilizing potential, or pregnancy rate over those observed
in the placebo controls in cases with primary idiopathic testicular f
ailure.