INTEGRATED GENETIC-MAP OF HUMAN-CHROMOSOME-2

Citation
S. Cox et al., INTEGRATED GENETIC-MAP OF HUMAN-CHROMOSOME-2, Annals of Human Genetics, 59, 1995, pp. 413-434
Citations number
35
Categorie Soggetti
Genetics & Heredity
Journal title
ISSN journal
00034800
Volume
59
Year of publication
1995
Part
4
Pages
413 - 434
Database
ISI
SICI code
0003-4800(1995)59:<413:IGOH>2.0.ZU;2-T
Abstract
A framework genetic map of human chromosome 2 is described, integratin g data from the Centre d'Etude du Polymorphisme Humain (CEPH) version 6 database, the CEPH chromosome 2 consortium database, the National In stitute of Health (NIH)/CEPH Collaborative Mapping group and other lab oratories. A comprehensive map is also presented, showing regional loc ations of a large number of additional loci. The framework map is used to identify an informative set of meiotic breakpoints within the CEPH families, and the utility of this information for mapping new markers is discussed. The degree of typing error within the data set is estim ated, as are the sex-specific interference parameters. A location data base for these genetic and additional cytogenetic data is constructed using algorithms which map genetic distances on to a physical scale, a nd the potential for this approach to aid the integration of genetic a nd physical data is examined.