PLATELET-ACTIVATING-FACTOR (PAF) AND THE FORMATION OF CHRONIC SUBDURAL-HEMATOMA - MEASUREMENT OF PLASMA PAF LEVELS AND ANTI-PAF IMMUNOGLOBULIN TITERS

Authors
HIRASHIMA Y ENDO S HAYASHI N KARASAWA K NOJIMA S TAKAKU A
Citation
Y. Hirashima et al., PLATELET-ACTIVATING-FACTOR (PAF) AND THE FORMATION OF CHRONIC SUBDURAL-HEMATOMA - MEASUREMENT OF PLASMA PAF LEVELS AND ANTI-PAF IMMUNOGLOBULIN TITERS, Acta neurochirurgica, 137(1-2), 1995, pp. 15-18
Citations number
23
Categorie Soggetti
Surgery,Neurosciences
Journal title
Acta neurochirurgica → ACNP
ISSN journal
00016268
Volume
137
Issue
1-2
Year of publication
1995
Pages
15 - 18
Database
ISI
SICI code
0001-6268(1995)137:1-2<15:P(ATFO>2.0.ZU;2-7
Abstract
In order to estimate the contribution of platelet-activating factor (P AF) to the formation of chronic subdural haematomas (CSH), we measured plasma PAF and anti-PAF antibody levels in head injured patients with and without CSH and normal volunteers. Plasma PAF and anti-PAF IgG le vels were higher in patients with CSH than in patients without CSH or in normal volunteers. Furthermore, plasma PAF and anti-PAF IgG levels increased in a time-dependent manner over the first 35 days following head injury. These data suggest that PAF may be involved in the genera tion of CSH.