IRRADIATION AND RESPONSIVENESS TO PAIN STIMULI IN RATS

Authors
RUTTEN EHJM DIRKSEN R CRUL BJP OOSTERVELD BJ VANEGMOND J
Citation
Ehjm. Rutten et al., IRRADIATION AND RESPONSIVENESS TO PAIN STIMULI IN RATS, Life sciences, 54(23), 1994, pp. 1815-1823
Citations number
26
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
54
Issue
23
Year of publication
1994
Pages
1815 - 1823
Database
ISI
SICI code
0024-3205(1994)54:23<1815:IARTPS>2.0.ZU;2-Y
Abstract
This study evaluates whether irradiation inhibits responses in pain in an animal model. We found that irradiation with doses of 10 Gy, 15 Gy and 17.5 Gy of the lumbar enlargement of the spinal cord inhibits the behavioural responses to the stimulus of the hot-plate. These doses w ere otherwise without effects. This data is discussed in view of the e ffects of irradiation of living cells, and we propose that a modificat ion of pain signal processing is accomplished. Similar considerations apply to the human condition.