PRODEPIN - A NEW PRODUCT OF THE ADRENOMEDULLIN (ADM) GENE HAS SYSTEMIC VASODILATOR ACTIVITY

Authors
LIPPTON H GAO YQ LIN B HEATON J FERRARA J DEVITO M GRANGER T PIGOTT J CHANG JK HYMAN A
Citation
H. Lippton et al., PRODEPIN - A NEW PRODUCT OF THE ADRENOMEDULLIN (ADM) GENE HAS SYSTEMIC VASODILATOR ACTIVITY, Life sciences, 54(23), 1994, pp. 409-412
Citations number
6
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
54
Issue
23
Year of publication
1994
Pages
409 - 412
Database
ISI
SICI code
0024-3205(1994)54:23<409:P-ANPO>2.0.ZU;2-A
Abstract
The purpose of the present study was to investigate the effects of pro ducts of the ADM gene other than ADM on systemic hemodynamics in the a nesthetized rat, rabbit, piglet, cat and dog. Bolus intravenous (i.v.) injections of rat proADM(22-41) (3-30 mu g) significantly decreased s ystemic arterial pressure (SAP) and systemic vascular resistance in th e anesthetized rat. Unlike ADM, rat proADM(22-41) markedly increased c ardiac output in the rat. Bolus i.v. injections of human proADM(22-41) up to 500 mu g had not effect in all species studied and rat proADM(2 2-41) had no effect in species other than the rat. The present data su ggest that rat proADM(22-41) is a novel product of the ADM gene other than ADM and possesses marked systemic vasodilator activity. The prese nt data also suggest that the hemodynamic activity of this peptide is species specific.