A FACILE SYNTHESIS OF [C-14] ENADOLINE YL)-1-OXASPIRO[4,5]DEC-8-YL]-4-BENZOFURANACETAMIDE

Authors
PU YM SCRIPKO J HUANG CC
Citation
Ym. Pu et al., A FACILE SYNTHESIS OF [C-14] ENADOLINE YL)-1-OXASPIRO[4,5]DEC-8-YL]-4-BENZOFURANACETAMIDE, Journal of labelled compounds & radiopharmaceuticals, 36(12), 1995, pp. 1183-1191
Citations number
10
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
36
Issue
12
Year of publication
1995
Pages
1183 - 1191
Database
ISI
SICI code
0362-4803(1995)36:12<1183:AFSO[E>2.0.ZU;2-D
Abstract
4-Chloromethylbenzofuran (10) was synthesized from 2,3-dimethylanisole in 7 steps. The corresponding Grignard reagent prepared from magnesiu m-anthracene complex reacts with (CO2)-C-14, SOCl2, and PD130812 succe ssively to give [C-14]enadoline (2), a non-peptide, selective kappa op ioid receptor agonist. This method could be readily modified for the r apid, one-pot synthesis of [C-11]enadoline.