Objective: To evaluate the effectiveness of hysterectomy in treating c
hronic pelvic pain, and to identify risk factors for persistent pelvic
pain. Methods: A group of 308 women who had hysterectomy for chronic
pelvic pain of at least 6 months' duration was followed-up for 1 year
after surgery, as part of a large, prospective, multicenter cohort stu
dy. Persistent pain was defined as a trichotomous variable, and ordina
l logistic regression was used to identify independent predictors of t
he trichotomous outcome. Results: Overall, 74% of women experienced co
mplete resolution of pelvic pain, 21% reported continued but decreased
pain, and 5% reported either unchanged or increased pain after hyster
ectomy. In unadjusted analyses, women at increased risk for persistent
pain leg, continued but decreased, and unchanged or increased) includ
ed those who were under age 30 (36 versus 22%, P < .05), had a history
of pelvic inflammatory disease (41 versus 25%, P < .05), were uninsur
ed or covered under Medicaid (41 versus 22%, P < .001), had no identif
ied pelvic pathology (38 versus 23%, P < .05), or had a history of at
least two pregnancies (31, 27, and 15% for those with at least four, t
wo or three, and one or none, respectively; P < .05). After adjustment
, an increased probability of persistent pain was observed among women
who had no identified pelvic pathology (odds ratio [OR] 1.9, 95% conf
idence interval [CI] 1.0-3.6), were uninsured or covered under Medicai
d (OR 2.3, 95% CI 1.2-4.3), or had experienced at least two pregnancie
s (OR 2.3, 95% CI 1.0-5.3). Conclusion: Most women with chronic pelvic
pain have long-term improvement after hysterectomy. However, up to 40
% of women in specific subgroups may continue to experience long-term
pain.