FUNCTIONS OF PRB AND P53 - WHATS THE CONNECTION

Authors
KOUZARIDES T
Citation
T. Kouzarides, FUNCTIONS OF PRB AND P53 - WHATS THE CONNECTION, Trends in cell biology, 5(12), 1995, pp. 448-450
Citations number
32
Categorie Soggetti
Cell Biology
Journal title
Trends in cell biology → ACNP
ISSN journal
09628924
Volume
5
Issue
12
Year of publication
1995
Pages
448 - 450
Database
ISI
SICI code
0962-8924(1995)5:12<448:FOPAP->2.0.ZU;2-H
Abstract
The pRb and p53 proteins have tumour suppressor functions and both are regulators of transcription. Their mechanisms of transcriptional regu lation are unrelated in many ways in contrast, it would appear, to the ir biological functions. This review highlights their biological conne ctions in the light of recent advances in understanding the mechanisms of pRb and p53 function.