H. Sato et al., ANGIOTENSIN-II (AII) INDUCED HYPERTENSION CHEMOTHERAPY (IHC) FOR UNRESECTABLE GASTRIC-CANCER - WITH REFERENCE TO RESECTION AFTER DOWN STAGING, World journal of surgery, 19(6), 1995, pp. 836-842
Angiotensin II induced hypertension chemotherapy (MC) is a drug delive
ry system for augmentation of anti-cancer effects on the experimental
basis of the functional difference of microcirculation between tumor a
nd normal tissue. Blood how in tumor tissue increased selectively when
the blood pressure was elevated by the infusion of angiotensin II, Tw
o randomized controlled trials (RCT) for advanced gastric cancer using
AFM regimen; a combination of adriamycin (ADM), 5-fluorouracil (5-FU)
, and mitomycin (MMC), showed increased response rate by IHC (response
rate: IHC/non-IHC; 42.9% vs 10.5% in RCT-1, and 31.3% vs 6.7% in RCT-
2, respectively). Toxicities were not different statistically between
groups, In phase II for stage IVB gastric cancer patients (the criteri
a according to the General Rules of the Gastric Cancer Study of Japane
se Research Society for Gastric Cancer), 5 complete response (CR) and
10 partial response (PR) (58%) were observed out of 26 unresectable ca
ses without prior chemotherapy, Moreover, 5 of 15 responders could rec
eive curative gastrectomy and obtained conclusive down staging (19%).
Here we discuss the role of enhancement of drug delivery for cancer ch
emotherapy on the basis of a series of clinical and experimental evide
nces.