PREPARATION AND BIOLOGICAL-ACTIVITY OF 7,27,27-HEXAFLUORO-1-ALPHA,25-DIHYDROXYVITAMIN-D-2

Authors
ISEKI K OISHI S NAMBA H TAGUCHI T KOBAYASHI Y
Citation
K. Iseki et al., PREPARATION AND BIOLOGICAL-ACTIVITY OF 7,27,27-HEXAFLUORO-1-ALPHA,25-DIHYDROXYVITAMIN-D-2, Chemical and Pharmaceutical Bulletin, 43(11), 1995, pp. 1897-1901
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
11
Year of publication
1995
Pages
1897 - 1901
Database
ISI
SICI code
0009-2363(1995)43:11<1897:PABO7>2.0.ZU;2-8
Abstract
A new fluorinated analog of vitamin D-2, 24-epi-26,26,26,27,27,27-hexa fluoro-1 alpha,25-dihydroxyvitamin D-2, was efficiently synthesized st arting from (R)-4-isopropyl-3-propionyl-2-oxazolidinone with high ster eochemical control, In all four physiological test systems, the fluori nated vitamin D, analog was found to be slightly less active than 1 al pha,25-dihydroxyvitamin D-3.