Patients with both severe atopic dermatitis (AD) and chronic myeloid l
eukemia, chronic hepatitis B, or chronic hepatitis C were treated with
interferon-alpha (IFN-alpha). IFN-alpha treatment improved AD. Moreov
er, there were also significant decreases in serum IgE and IgG4 levels
and in in vitro spontaneous IgE and IgG4 production by patients' mono
nuclear cells.