In areas where the prevalence of methicillin-resistant Staphylococcus
aureus (MRSA) is very low, aggressive strategies, which appear to have
been effective, such as those used in the Netherlands and western Aus
tralia, may be feasible. In hospitals where MRSA is epidemic or highly
endemic, less rigorous strategies are appropriate. However, which iso
lation techniques and barrier precautions are optimal is controversial
. In addition, there is no consensus regarding the epidemiological imp
ortance of environmental contamination. Rapid detection of MRSA, promp
t implementation of barrier precautions and prospective surveillance a
re essential components of a successful control programme. Eradicating
nasal carriage of MRSA among patients and personnel can be useful dur
ing epidemics, but the cost-effectiveness of using this approach in ho
spitals where the prevalence of MRSA is low is unknown. Additional stu
dies of this issue need to include surveillance for mupirocin-resistan
t strains.