F. Demartin et al., SYNTHESIS, NMR-STUDY, AND X-RAY STRUCTURE OF 2-(N-METHYL-N'-CYANO-N''-ETHYLGUANIDINO) THIOTRIPHENYLPHOSPHINEGOLD(I), Journal of inorganic biochemistry, 60(4), 1995, pp. 233-243
The reaction between cimetidine in a methanolic solution of KOH and a
dichloromethane solution of PPh(3)AuCl affords a new compound with for
mula [L-Au-PPh(3)] (I) (L = 2-(N-methyl-N'-cyano-N ''-ethylguanidino)t
hiolate), the thiolato ligand resulting from cleavage of one of the th
ioether bonds of cimetidine. (I) has been characterized by elemental a
nalysis, infrared, and H-1 and C-13 NMR spectroscopy. Single crystal x
-ray structure determination shows that the gold atom is linearly coor
dinated by a phosphine ligand (Au-P 2.258(1) Angstrom) and by an S ato
m (Au-S 2.282(1) Angstrom) of the thiolato ligand. Crystal data: tricl
inic, space group P (1) over bar with a = 8.848(1), b = 11.343(3), c =
12.107(3) Angstrom, alpha = 87.63(1), beta = 85.24(1), gamma = 79.89(
1)degrees, R = 0.024 for 3673 reflections with I > 3 sigma(I).