RES-701-2, RES-701-3 AND RES-701-4, NOVEL AND SELECTIVE ENDOTHELIN TYPE-B RECEPTOR ANTAGONISTS PRODUCED BY STREPTOMYCES SP .1. TAXONOMY OF PRODUCING STRAINS, FERMENTATION, ISOLATION, AND BIOCHEMICAL-PROPERTIES

Authors
OGAWA T OCHIAI K TANAKA T TSUKUDA E CHIBA S YANO K YAMASAKI M YOSHIDA M MATSUDA Y
Citation
T. Ogawa et al., RES-701-2, RES-701-3 AND RES-701-4, NOVEL AND SELECTIVE ENDOTHELIN TYPE-B RECEPTOR ANTAGONISTS PRODUCED BY STREPTOMYCES SP .1. TAXONOMY OF PRODUCING STRAINS, FERMENTATION, ISOLATION, AND BIOCHEMICAL-PROPERTIES, Journal of antibiotics, 48(11), 1995, pp. 1213-1220
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
11
Year of publication
1995
Pages
1213 - 1220
Database
ISI
SICI code
0021-8820(1995)48:11<1213:RRARNA>2.0.ZU;2-E
Abstract
RES-701-2, -3 and -4, novel cyclic peptide endothelin antagonists, wer e isolated from the culture broths of Streptomyces sp. RE-701 and RE-8 96. RES-701s selectively inhibited the ET-1 binding to endothelin type B receptor (ET(B) receptor) with IC50 values ranging from 5 to 20nM. Taxonomy of the producing strains, fermentation, isolation and biochem ical properties of RES-701s are described.