Sm. Eshita et al., BACILLOMYCIN L(C), A NEW ANTIBIOTIC OF THE ITURIN GROUP - ISOLATIONS,STRUCTURES, AND ANTIFUNGAL ACTIVITIES OF THE CONGENERS, Journal of antibiotics, 48(11), 1995, pp. 1240-1247
Bacillomycin L(c), a new antifungal antibiotic of the iturin class, wa
s isolated from a strain of Bacillus subtilis as a set of five five co
ngeners. The structure as determined by chemical and spectrometric ana
lyses has been shown to differ from that of bacillomycin L by sequence
changes from aspartate-1 to asparagine-1 and from glutamine-5 to glut
amate-5. The five congeners differ from each other only in the structu
re of the aliphatic side chain of the constituent beta-amino acid. The
hydrophobicity of the beta-amino acid affects the antifungal activity
of the congener, as activity increased in the order of increased cong
ener retention on a reversed-phase HPLC column.