STRUCTURE DETERMINATION OF RIBOSYLATED RIFAMPICIN AND ITS DERIVATIVE - NEW INACTIVATED METABOLITES OF RIFAMPICIN BY MYCOBACTERIAL STRAINS

Authors
MORISAKI N KOBAYASHI H IWASAKI S FURIHATA K DABBS ER YAZAWA K MIKAMI Y
Citation
N. Morisaki et al., STRUCTURE DETERMINATION OF RIBOSYLATED RIFAMPICIN AND ITS DERIVATIVE - NEW INACTIVATED METABOLITES OF RIFAMPICIN BY MYCOBACTERIAL STRAINS, Journal of antibiotics, 48(11), 1995, pp. 1299-1303
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
11
Year of publication
1995
Pages
1299 - 1303
Database
ISI
SICI code
0021-8820(1995)48:11<1299:SDORRA>2.0.ZU;2-7
Abstract
Rifampicin (1) was converted into two inactivated products RIP-Ma and RIP-Mb by Mycobacterium smegmatis DSM43756. MS, NMR and chromatographi c analysis showed the compounds to be 3-formyl-23-[O-(alpha-D-ribofura nosyl)]rifamycin SV (6) and 23-[O-(alpha-D-ribofuranosyl)]rifampicin ( 7), respectively.