NEUROHORMONAL CONTROL OF PANCREATIC EXOCR INE SECRETION BY INTRAILEALAND INTRACOLONIC NUTRIENTS

While the duodenum controls pancreatic exocrine secretion mainly via s timulatory mechanisms, intraileal and intracolonic nutrients have main ly inhibitory effects on the postprandial and interdigestive pancreati c secretion, which are described in particular. The inconsistent findi ngs in dogs in contrast to other species (cat, rat, human) referring t o the effects of intraileal nutrients are discussed. Possible mechanis ms for the neurohormonal mediation of the effects of intraileal and in tracolonic nutrients on the pancreatic secretion as well as the possib le physiological importance of these effects are discussed.