REVIEW OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE - BIOLOGICAL ASPECTS,METHODS OF DETECTION, AND SELECTED DIAGNOSTIC APPLICATIONS

Authors
CHILOSI M PIZZOLO G
Citation
M. Chilosi et G. Pizzolo, REVIEW OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE - BIOLOGICAL ASPECTS,METHODS OF DETECTION, AND SELECTED DIAGNOSTIC APPLICATIONS, Applied immunohistochemistry, 3(4), 1995, pp. 209-221
Citations number
138
Categorie Soggetti
Immunology
Journal title
Applied immunohistochemistry → ACNP
ISSN journal
10623345
Volume
3
Issue
4
Year of publication
1995
Pages
209 - 221
Database
ISI
SICI code
1062-3345(1995)3:4<209:ROTDT->2.0.ZU;2-H
Abstract
Terminal deoxynucleotidyl transferase (TdT) is a well-established mark er of immature hematopoietic cells which is widely used for the diagno sis and characterization of acute leukemias and lymphoid neoplasms. In this review we describe the biology and histopathology of TdT, includ ing a critical discussion of the clinical applications and the various technical approaches for analyzing different pathologic samples.