LIPASE-CATALYZED RESOLUTIONS OF SOME ALPHA,ALPHA-DISUBSTITUTED 1,2-DIOLS IN ORGANIC-SOLVENTS - NEAR ABSOLUTE REGIO AND CHIRAL RECOGNITION

Authors
HOF RP KELLOGG RM
Citation
Rp. Hof et Rm. Kellogg, LIPASE-CATALYZED RESOLUTIONS OF SOME ALPHA,ALPHA-DISUBSTITUTED 1,2-DIOLS IN ORGANIC-SOLVENTS - NEAR ABSOLUTE REGIO AND CHIRAL RECOGNITION, Tetrahedron : asymmetry, 5(4), 1994, pp. 565-568
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
4
Year of publication
1994
Pages
565 - 568
Database
ISI
SICI code
0957-4166(1994)5:4<565:LROSA1>2.0.ZU;2-Z
Abstract
Several racemic 1,2-diols bearing a tertiary benzylic alcohol stereoge nic center can be esterified regioselectively by vinyl acetate using l ipases and esterases in organic media. With the correct choice of enzy me and if the non-phenyl substituent at the tertiary center is unsatur ated, E values of > 250 can be achieved.