SYNTHETIC PEPTIDE RECEPTOR MIMICS - HIGHLY STEREOSELECTIVE RECOGNITION IN NONCOVALENT MOLECULARLY IMPRINTED POLYMERS

Authors
RAMSTROM O NICHOLLS IA MOSBACH K
Citation
O. Ramstrom et al., SYNTHETIC PEPTIDE RECEPTOR MIMICS - HIGHLY STEREOSELECTIVE RECOGNITION IN NONCOVALENT MOLECULARLY IMPRINTED POLYMERS, Tetrahedron : asymmetry, 5(4), 1994, pp. 649-656
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
4
Year of publication
1994
Pages
649 - 656
Database
ISI
SICI code
0957-4166(1994)5:4<649:SPRM-H>2.0.ZU;2-D
Abstract
Ligand-receptor recognition has been studied in a molecularly imprinte d polymer (MIP) prepared against N-Ac-L-Phe-L-Trp-OMe. The non-ionic n on-covalent interaction based recognition was evaluated using the poly mers as chiral HPLC stationary phases. Marked regio-, enantio- and dia stereo- ligand selectivity were demonstrated with enantiomer separatio n Factors of up to 17.8. The interaction of a series of related struct ures with the MIP receptor site has provided insight concerning its na ture and the recognition mechanisms.