REGIOSELECTIVITY AND ENANTIOSELECTIVITY OF PSEUDOMONAS-CEPACIA LIPASEIN THE TRANSESTERIFICATION OF 2-SUBSTITUTED-1,4-BUTANEDIOLS

Authors
FERRABOSCHI P GRISENTI P MANZOCCHI A SANTANIELLO E
Citation
P. Ferraboschi et al., REGIOSELECTIVITY AND ENANTIOSELECTIVITY OF PSEUDOMONAS-CEPACIA LIPASEIN THE TRANSESTERIFICATION OF 2-SUBSTITUTED-1,4-BUTANEDIOLS, Tetrahedron : asymmetry, 5(4), 1994, pp. 691-698
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
4
Year of publication
1994
Pages
691 - 698
Database
ISI
SICI code
0957-4166(1994)5:4<691:RAEOPL>2.0.ZU;2-L
Abstract
The transesterification of 2-substituted-1,4-butanediols 1a, 2a and 3a with vinyl acetate catalyzed by the Pseudomonas cepacia lipase in org anic solvents affords preferentially the 1-acetate, the highest regios electivity having been found for the epoxydiol 3a, which is enantiosel ectively resolved [86% ee for the unreacted (S)-(-)-3a].