IN-VITRO GROWTH-INHIBITION ACTIVITIES OF RECOMBINANT FELINE INTERFERON ON ALL LINES DERIVED FROM CANINE TUMORS

To evaluate the anti-tumour effect of recombinant feline interferon (r FeIFN) against canine neoplastic cells, the antiproliferation and anti -colony-forming activities of rFeIFN were investigated in vitro, using four cell lines derived from canine tumours; oral acanthomatous epuli s (MCA-BI), mammary benign mixed tumour (MCM-B2), squamous cell carcin oma (CSCC), and malignant melanoma (CMC-I). The rFeIFN had a dose-depe ndent inhibitory effect on the cell growth and colony formation of all the cell lines, although the degree of inhibition was lower than that in the feline cell lines used as a positive control, and the sensitiv ity of the cells to rFeIFN differed.