SYNTHESIS OF AN OXYAMIDE LINKED NUCLEOTIDE DIMER AND INCORPORATION INTO ANTISENSE OLIGONUCLEOTIDE SEQUENCES

Authors
BURGESS K GIBBS RA METZKER ML RAGHAVACHARI R
Citation
K. Burgess et al., SYNTHESIS OF AN OXYAMIDE LINKED NUCLEOTIDE DIMER AND INCORPORATION INTO ANTISENSE OLIGONUCLEOTIDE SEQUENCES, Journal of the Chemical Society, Chemical Communications, (8), 1994, pp. 915-916
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
8
Year of publication
1994
Pages
915 - 916
Database
ISI
SICI code
0022-4936(1994):8<915:SOAOLN>2.0.ZU;2-8
Abstract
Two derivatives of thymidine, a 5'-protected 3'-hydroxylamine and 5'-c arboxy-3'-protected compound, were prepared and coupled to form an oxy amide-linked dinucleotide analogue; this dimer was incorporated into a n oligodeoxynucleotide then shown to anneal to complementary DNA with nearly the same affinity as the natural sequence.