ASYMMETRIC TOTAL SYNTHESIS OF (-7-DEOXYPANCRATISTATIN())

Authors
TIAN XR MAURYA R KONIGSBERGER K HUDLICKY T
Citation
Xr. Tian et al., ASYMMETRIC TOTAL SYNTHESIS OF (-7-DEOXYPANCRATISTATIN()), Synlett, (11), 1995, pp. 1125
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
11
Year of publication
1995
Database
ISI
SICI code
0936-5214(1995):11<1125:ATSO(>2.0.ZU;2-4
Abstract
An asymmetric synthesis of 7-deoxypancratistatin 1 has been accomplish ed starting from diol 2 via two pathways in overall yields of 2.6 and 3.0%, respectively. The key step involved the regioselective ring open ing of tosylaziridine 3 or the new carbomethoxyaziridine 15 with a hig her-order cuprate and the cyclization of urethane 11.