CYCLIZATION OF A CHIRAL N-CROTYL METHOXYCARBONYLACETAMIDE MEDIATED BYMN(III) - AN EASY ENTRY TO (R)-3-PYRROLIDINEACETIC ACID

Authors
CARDILLO B GALEAZZI R MOBBILI G ORENA M
Citation
B. Cardillo et al., CYCLIZATION OF A CHIRAL N-CROTYL METHOXYCARBONYLACETAMIDE MEDIATED BYMN(III) - AN EASY ENTRY TO (R)-3-PYRROLIDINEACETIC ACID, Synlett, (11), 1995, pp. 1159
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
11
Year of publication
1995
Database
ISI
SICI code
0936-5214(1995):11<1159:COACNM>2.0.ZU;2-L
Abstract
The N-crotyl methoxycarbonylacetamide 3, containing (S)-phenylethylami ne as the chiral auxiliary, was cyclised with Mn(III), to give an easi ly separable mixture of diastereomeric pyrrolidin-2-ones in 70:30 d.r. The major isomer is a key intermediate to (R)-3-pyrrolidineacetic aci d, inhibitor of GABA uptake in astrocytes.