LINEAR PHARMACOKINETICS OF A NEW INOTROPIC AGENT

Authors
TRENQUE T BARRE J LAMIABLE D TILLEMENT JP
Citation
T. Trenque et al., LINEAR PHARMACOKINETICS OF A NEW INOTROPIC AGENT, Arzneimittel-Forschung, 44-1(4), 1994, pp. 471-473
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
44-1
Issue
4
Year of publication
1994
Pages
471 - 473
Database
ISI
SICI code
0004-4172(1994)44-1:4<471:LPOANI>2.0.ZU;2-U
Abstract
The dose-dependent pharmacokinetics of N,N'-dicyclo-propyl -methyl-pip erazine-dichlorhydrate (Ino 2628 CZ, CAS 82909-97-5), a new inotropic compound, was studied after 4 intravenous infusions in 3 subjects and 4 orally administered doses in 6 subjects. Plasma and urine levels wer e determined over 72 h. The results show that the pharmacokinetics of Ino 2628 CZ was dose proportional over the intravenous and oral dose r ange of 100 to 400 mg.