SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL SERIES OF SULFONATEESTER-CONTAINING 1,3,4-OXADIAZOLE DERIVATIVES WITH ANTICIPATED HYPOGLYCEMIC ACTIVITY

Four series of 2,5-disubstituted 1,3,4-oxadiozole derivatives (IV, VII , IX and X) have been synthesized from 4-(4-(Z)-[p-(benzenesulfonyloxy ) phenylmethylene]-5-oxo-1-phenyl-2- imidazolin-1-yl) benzoyl hydrazin e derivative (II) with a view to investigate the effect of different s tructural changes in the oxadiazole moiety on the pharmacological acti vity of these compounds as possible hypoglycemic agents. The structure of the synthesized compounds was inferred from elemental and spectral data and their hypoglycemic effect, antimicrobial activity and toxici ty were evaluated. Twelve of these compounds were effective, when admi nistered at an oral dose of 100 mg/kg, to induce marked reduction in b lood glucose level.