ANTIULCER EFFECT OF ETHYLPROPOXY)ANILINO]-6-OXO-5-PYRIMIDINECARBOXYLIC ACID OIL EXPERIMENTAL GASTRIC-ULCERS IN RATS

The effects of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyr imidinecarboxylic acid (MAR-99, CAS 98772-05-5) on various experimenta l gastric ulcers were studied in rats. MAR-99 (3-100 mg/kg, p.o. or i. d.) showed the anti-ulcer effect in Shay-, stress, acetylsalicylic aci d (ASA)- and compound 48/80-ulcer models and significantly accelerated healing of acetic acid-induced gastric ulcer in rats. In addition, MA R-99 (1-10 mg/kg p.o.) decreased dose-dependently the gastric mucosal damage induced by necrotizing agents such as 99.5% ethanol, 0.6N HCl a nd 0.2N NaOH. These results indicate that MAR-99 may be useful for the treatment of gastric ulcer in human.